Projects

 

Synaptic circuit organization of motor cortex: Synaptic circuits in motor and related areas of cortex engage in neural operations underlying diverse aspects of behavior – motor control, executive functions, working memory, sensorimotor integration, and more. We study synaptic circuit organization across multiple levels, from ion channels to long-range circuits, focusing on cell-type-specific connectivity.

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In vivo analysis of motor cortex activity: We are also interested in understanding how these cells and circuits are involved in generating motor behavior. We use multiple methods to monitor (linear array electrophysiology, EMGs, imaging) and manipulate (optogenetic activation and silencing) the activities of corticospinal and other projection neurons in sensorimotor circuits.

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"Two thumbs up" - how mice use their hands and jaws for oromanual dexterity: Using high-speed close-up video, we identified a set of kinematic building-blocks and an outsized role for the thumbs as mice handle food. We are interested in understanding how multiple body parts work together during complex ethological behaviors, and in determining the underlying neuronal circuit dynamics.